Planar-bilayer activities of linear oligoester bolaamphiphiles

• Jonathan K. W. Chui,
• Thomas M. Fyles and
• Horace Luong

Beilstein J. Org. Chem. 2011, 7, 1562–1569, doi:10.3762/bjoc.7.184

• voltage-dependent. The varied and irregular activities were summarized with the aid of a recently developed “activity-grid” method. Keywords: activity grid; single-molecule studies; synthetic ion channels; voltage clamp experiment; Introduction Ion channels modulate conductance in cell membranes, and

• of single or small groups of molecules, and this current can be monitored with millisecond time resolution or faster. Thus, this method can report not only the flux but also the structural dimensions and dynamic properties of the channel with high sensitivity; however, the voltage-clamp experiment

• voltage-clamp experiment. Synthesis of phthalate compounds. Voltage-dependent current (averaged over 200 s) for compounds 1 and 2. A is the pre-exponential of the fitting, whereas b is the exponent. Supporting Information Supporting Information File 282: Synthesis procedures, spectroscopic